Search the Healthy Living Web Site


Advanced Search

This Week's Discussion Topics

Home | Message Board | About Us | Alternative | Bookstore | Exercise | Health Issues | Gatherings | Member Photo Gallery | Newsletters | Nutrition | Our Stories | Recipes | Recommended Software | Resources | Weight Maintenance | Site Map | Contact Us
 


Healthy Living

Adverse Cardiovascular and Central Nervous System Events Associated with Dietary Supplements Containing Ephedra Alkaloids

Cardio-vascular system

Background Dietary supplements that contain ephedra alkaloids(sometimes called ma huang) are widely promoted and used in the United States as a means of losing weight and increasing energy. In the light of recently reported adverse events related to use of these products, the Food and Drug Administration (FDA)has proposed limits on the dose and duration of use of such supplements. The FDA requested an independent review of reports of adverse events related to the use of supplements that contained ephedra alkaloids to assess causation and to estimate the level of risk the use of these supplements poses to consumers.

Methods We reviewed 140 reports of adverse events related to the use of dietary supplements containing ephedra alkaloids that were submitted to the FDA between June 1, 1997, and March 31, 1999. A standardized rating system for assessing causation was applied to each adverse event.

Results Thirty-one percent of cases were considered to be definitely or probably related to the use of supplements containing ephedra alkaloids, and 31 percent were deemed to be possibly related. Among the adverse events that were deemed definitely, probably,or possibly related to the use of supplements containing ephedra alkaloids, 47 percent involved cardiovascular symptoms and 18 percent involved the central nervous system. Hypertension was the single most frequent adverse effect (17 reports), followed by palpitations, tachycardia, or both (13); stroke (10); and seizures (7). Ten events resulted in death, and 13 events produced permanent disability, representing 26 percent of the definite,probable, and possible cases.

Conclusions The use of dietary supplements that contain ephedra alkaloids may pose a health risk to some persons. These findings indicate the need for a better understanding of individual susceptibility to the adverse effects of such dietary supplements.

Source: New England Journal of Medicine Volume 343:1833-1838 December 21, 2000 Number 25

Copyright © 1998-2002 SLM & Healthy Living
All Rights Reserved

Back to Top


Home | Message Board | About Us | Alternative | Bookstore | Exercise | Health Issues | Gatherings | Member Photo Gallery | Newsletters | Nutrition | Our Stories | Recipes | Recommended Software | Resources | Weight Maintenance | Site Map | Contact Us